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801. All of the following are true about cytokines EXCEPT:
A. Communicators
B. Interleukine-I
C. TNF
D. Perforin ✅
802. The following viruses are associated with congenital infection EXCEPT ONE:
A. Rubella virus
B. CMV
C. Varicella
D. RSV ✅
803. The following statements regarding HIV are true EXCEPT ONE:
A. It belongs to the family Reteroviridae
B. It is an oncogenic virus ✅
C. The virus is present in all body fluids
D. The sexual route is the main mode of transmission
804. The following viruses are transmitted by the fecal-oral route EXCEPT ONE:
A. HAV
B. HEV
C. HDV
D. Entero ✅
805. The following viruses can be transmitted sexually EXCEPT ONE:
A. HIV
B. HBV
C. HSV-2
D. Rubella ✅
806. Which of following is a segmented ds-RNA virus?
A. Togavirus
B. HAV
C. Rotavirus ✅
D. Parvovirus
807. All the following viruses are transmitted by respiratory routes EXCEPT ONE:
A. Human papilloma virus ✅
B. Rhinovirus
C. Adenovirus
D. Measles virus
808. All the following viruses are disseminated throughout the body EXCEPT ONE:
A. HIV
B. HBV
C. Rabies virus
D. Human papilloma virus ✅
809. An important defense function of cytotoxic T lymphocytes in viral infection is to:
A. Lyse virus infected cells ✅
B. Fragment viral nucleic acid by nucleases
C. Neutralize free virus particles
D. Lyse viral capsid
810. All of the following association are true EXCEPT ONE:
A. CMV causes heterophil-negative mononucleosis
B. Mumps virus can cause meningitis
C. Poliovirus can cause paralytic disease
D. Astrovirus causes gastroenteritis only in adults ✅
811. The bacterial flagellin is detected by which TLR?
A. TLR2
B. TLR6
C. TLR5 ✅
D. TLR9
812. Each of the following diseases is associated with infection by picornaviruses EXCEPT ONE:
A. Myocarditis
B. Hepatitis
C. Meningitis
D. Mononucleosis ✅
813. Certain viruses have been associated with birth defects, these teratogenic viruses include EXCEPT:
A. Rubella virus
B. CMV
C. VZV
D. Rhinovirus ✅
814. Which one of the following statements concerning mumps is CORRECT?
A. The testes, ovaries and pancreas can be involved ✅
B. There is no vaccine against mumps
C. Passive immunization is the only means of preventing the disease
D. Second episodes of mumps can occur, since there are 2 serotypes
815. Each of the following statements concerning HAV is correct EXCEPT ONE:
A. The initial site of viral replication is the GIT
B. The diagnosis is usually made by isolating the virus in cell culture ✅
C. HAV commonly causes asymptomatic infection in children
D. It is a member of the family picornaviridae
816. All the following viruses belong to the Picornaviridae EXCEPT ONE:
A. Rhinoviruses
B. Poliovirus
C. Rabies virus ✅
D. Echovirus
817. Acute hemorrhagic conjunctivitis is caused by which of the following viruses:
A. Coronovirus
B. Reovirus
C. Rhinovirus
D. Enterovirus ✅
818. Epidemic pleurodynia and mycarditis are both caused by:
A. Group B Coxsackievirus ✅
B. Polymavirus
C. RSV
D. Reovirus
819. All the following are acceptable specimens for the isolation enterovirus EXCEPT ONE:
A. Feces
B. CSF
C. Throat secretions
D. Urine ✅
820. When infectious mononucleosis is suspected, all the following tests can be useful EXCEPT ONE:
A. IgM antibody to EB-VCA
B. IgG antibody to EB-VCA
C. Antibody to EB-NAs
D. Culture ✅
821. Which of the following statements best describes rotavirus?
A. It is an RNA virus
B. Tests for detection of antigen are rarely useful ✅
C. It is rarely a nosocomial pathogen
D. Person-to-person transmission is rare
822. Infectious mononucleosis is characterized by which of the following statements?
A. It is cause by rhabdovirus
B. The causative pathogen is an EBV ✅
C. Affected person respond to treatment with the production of heterophil antibodies
D. Ribavirin is the treatment of choice
823. The most sensitive method of detecting infection by CMV in the newborn is:
A. Isolation of virus
B. Detection of IgM antibody by IF
C. Direct detection of antigen by ELISA ✅
D. Detection of complement fixing antibodies
824. All the following statements about cytomegalovirus infection are true EXCEPT:
A. It can be cultured from RBCs of infected persons ✅
B. It can be transmitted transplacently
C. It can be activated by immunosuppressive agents
D. It can cause retinitis
825. All the following statements about human rotaviruses are true EXCEPT that they:
A. Produce an infection that is seasonally distributed peaking in fall and winter
B. Produce cytopathic effects in many conventional cell culture systems
C. Can be sensitively and rapidly detected in stools by the ELISA technique
D. Have been implicated as a major etiologic agent of infantile gastroenteritis.
826. A gene for insulin has been inserted into a vector for the purpose of obtaining its protein product only. Such a vector is called
A. Expression vector ✅
B. Suppression vector
C. Storage vector for genomic library
D. None of the above
827. MHC-I molecules make complex with which immune cells to kill intracellular antigens.
A. Neutrophils
B. TH cells
C. CD68 cells
D. Tc or cytotoxic T-cells ✅
828. The development, maturation and differentiation of T-lymphocytes occur in which organ?
A. Bursa of Fabricious
B. Liver
C. Thymus ✅
D. Tonsils
829. Birna viruses destroy which organ in chicken
A. Heart
B. Bursa of Fabricious ✅
C. Lungs
D. Thymus
830. Example of an obligate anaerobic bacterium is
A. Bacillus anthracis
B. Brucella abortus
C. Clostridium tetani ✅
D. Salmonella
831. Which antibody class is mainly involved in mucosal immunity?
A. IgY
B. IgA ✅
C. IgD
D. IgE
832. The oldest and traditionally used adjuvant in vaccines is:
A. BCG
B. ISCOMS
C. Alum ✅
D. Montanide
833. A plasmid consisting of its own DNA with a foreign DNA inserted into it is called
A. Recombinant plasmid ✅
B. Non-coding DNA
C. Junk DNA
D. None of the above
834. The extra chromosomal, self-replicating, double stranded, closed, circular DNA molecules are called:
A. Plasmids ✅
B. Phages
C. Viruses
D. Chloroplasts
835. The jumping genes in bacterial DNA are called as
A. Volutin
B. Endosomes
C. Histones
D. Transposons ✅
836. TTS is used against tetanus and is an example of
A. DNA vaccine
B. Attenuated vaccine
C. Sub-unit vaccine ✅
D. Autogenous vaccine
837. A gene produced for rDNA technology contains a gene from one organism joined to the regulatory sequence of another gene. Such a gene is called:
A. Oncogene
B. Junk gene
C. Chimeric gene ✅
D. Oncogene
838. Which Ab class is not present in chicken?
A. IgY
B. IgG ✅
C. IgM
D. IgD
839. A recombinant DNA molecule is produced by joining together
A. One mRNA with a DNA segment
B. One mRNA with a tRNA segment
C. Two mRNA molecules
D. Two DNA segments ✅
840. A group of genetically similar organisms obtained by a sexual reproduction is called
A. Clone
B. Population ✅
C. Assembly
D. None of these
841. After Gram’s staining, Gram positive bacteria are:
A. Green
B. Yellow
C. Red
D. Blue/violet ✅
842. Example of yeast is
A. Mucor
B. Rhizopus
C. Candida albicans ✅
D. Penecillium
843. Mycolic acid is present in cell wall ______.
A. Listeria
B. Mycoplasma
C. Staphylococcus
D. Mycobacterium ✅
844. To be useful in the preparation of recombinant DNA, a plasmid must have
A. No origin of replication
B. An origin of replication ✅
C. The ability to alternate between the linear and circular forms
D. Restriction endonuclease activity
845. The first human protein produced through recombinant DNA technology is
A. Insulin ✅
B. Erythropoitin
C. Interferon
D. Somatostatin
846. Humulin, a genetically engineered insulin was produced and marketed for the first time by
A. Biocon India Limited
B. Glaxo
C. Eli Lilly and Company ✅
D. Cipla
847. In one of the techniques of recombinant insulin production the genes for α and β polypeptides were inserted into the plasmid by the side of
A. Ori
B. β-galactosidase gene ✅
C. Antibiotic resistant gene
D. Restriction endonuclease gene
848. Endonucleases, a group of enzymes cleave DNA.
A. Externally
B. Internally ✅
C. Both ‘A’ and ‘B’
D. Neither ‘A’ nor ‘B’
849. Insulin, a protein, consisting of
A. 2 Polypeptide chains ✅
B. 3 Polypeptide chains
C. 4 Polypeptide chains
D. More than 4 Polypeptides chains
850. Before the production of recombinant insulin, insulin for the treatment of diabetes in human was obtained from:
A. Healthy humans
B. Dead human body
C. Cows and pigs ✅
D. Dogs and cats
851. The first licensed drug produced through genetic engineering is:
A. Interferon
B. Insulin ✅
C. Penicillin
D. Somatotropin
852. The plasmid generally used for the production of recombinant insulin is:
A. RK 646
B. Ti plasmid
C. ACY 17
D. pUC 18 ✅
853. Rauolfia serpentine, to save this plant under the threat of extinction, which of the following techniques is useful?
A. Genetic engineering
B. DNA finger printing
C. Hybridoma technology
D. In vitro culture ✅
854. ______ are popularly called “Molecular stichers”.
A. Restriction Endonuclease
B. Ligases ✅
C. RNA polymerase
D. DNA polymerase
855. Restriction endonucleases have ability of cutting:
A. DNA at random sites
B. DNA at specific sites ✅
C. Both ‘A’ and ‘B’
D. DNA and RNA at random sites
856. A clone is a group of organisms produced by:
A. Asexual method and genetically similar ✅
B. Asexual method and genetically dissimilar
C. Sexual method and genetically similar
D. Sexual method and genetically dissimilar
857. Expression vectors are those:
A. Produce protein products ✅
B. Used for genomic libraries
C. Used for chromosome synthesis
D. Used for finger printing
858. E. coli is generally used for gene cloning because:
A. It supports the replication of recombinant DNA
B. It is easy to transform
C. It is free from elements that interferes with replication and recombination of DNA
D. All of these ✅
859. An ideal plasmid to be used for recombinant DNA technology must have:
A. Minimum amount of DNA
B. Relaxed replication control
C. One recognition site for one restriction endonuclease
D. All of these ✅
860. Restriction endonucleases cut DNA at a specific site that is known as:
A. Ligation site
B. ori
C. Restriction site ✅
D. Replication site
861. Transfer of recombinant plasmid into E. coli needs:
A. Heat treatment
B. UV-rays treatment
C. MgCl2 treatment ✅
D. lysis
862. During recombinant insulin synthesis, the bond between insulin polypeptide and galactosidase can be removed by using:
A. Cyanogen bromide ✅
B. Chymotrypsin
C. Carboxy peptidase
D. Amylase
863. Which of the following statement about a vector is correct?
A. All vectors are plasmids only
B. Plasmids, phages can be used as vectors ✅
C. Fungi can also be used as vectors
D. Cyanobacteria can also be used as vectors
864. Which of the following statement about plasmids is correct?
A. Plasmids are present in bacteria only
B. Plasmids are present in all organisms
C. Plasmids present in bacteria and phages
D. Plasmids present in plants and animals ✅
865. ____is autonomously replicating minichromosome.
A. Virus
B. Phage
C. Plasmid ✅
D. Lichen
866. Which one of the following statement are not attributed to plasmids?
A. They are circular DNA molecule
B. They have antibiotic resistant genes
C. They have the ability of autonomous replication
D. They have DNA that is as long as chromosomal DNA ✅
867. DNA finger printing was first developed by:
A. David Suzuki
B. Khorana
C. Alec Jaffreys ✅
D. Gilbert
868. Which one of the following statements about plasmids is correct?
A. Plasmids are mobile. ✅
B. Plasmids are made up of RNA and proteins.
C. Plasmids are present in eukaryotes.
D. Plasmids are present in fungi.
869. Which one of the following statements about Restriction Endonuclease (RE) is TRUE?
A. All “RE” cut DNA at specific sites ✅
B. All “RE” cut DNA at random sites
C. All “RE” join DNA segments at specific sites
D. All “RE” join DNA at random sites
870. Transgenic organisms are:
A. Produced by gene transfer technology ✅
B. Extinct organisms
C. Naturally occurring and endemic
D. Produced by traditional plant breeding technique
871. Restriction endonucleases, when present in a host cell act on foreign DNA molecule and cleave them, but they do not act on host DNA molecule. It happens because:
A. Restriction endonuclease cannot act on host DNA
B. Host DNA is packed into chromosomes
C. Host DNA is methylated hence restriction endonucleases can’t act. ✅
D. Restriction endonucleases become inactive when they reach host DNA
872. The presence of Restriction endonucleases was postulated in 1960 by:
A. Khorana
B. Watson
C. Crick
D. Arber ✅
873. The scientists who won Nobel prize for physiology for their discovery of restriction endonucleases are:
A. Jacob and Monad
B. Smith, Nathans and Arber ✅
C. Watson and Crick
D. Alec Jaffreys and Milstein
874. Restriction endonucleases are also called:
A. Molecular scissors ✅
B. Molecular stichers
C. DNA synthesis
D. Polymerases
875. In restriction endonuclease EcoR1, “E” stands for
A. Extraction
B. The first letter of the genus in which it is present ✅
C. Endonuclease
D. Endangered
876. VNTR is
A. Variable nucleotide triplet repeat
B. Variable nucleoside tandem repeat
C. Variable nucleoside triplet repeat
D. Variable number tandem repeats ✅
877. Restriction endonucleases recognize specific sequences on DNA called:
A. Non-coding sequences
B. Satellites
C. Palindromes with rotational symmetry ✅
D. Tandem repeats
878. Main tools required for recombinant DNA technology are:
A. Vector, desired gene
B. Vector, desired gene, mRNA of desired gene, host, restriction enzymes, ligases ✅
C. Desired gene, host, vector
D. Vector, desired gene, mRNA of desired gene, host
879. Prior to the production of recombinant insulin, insulin obtained from cows and pigs were given to patients. Some of the problems faced by this treatment was:
A. The insulin was not active
B. In some humans it induced antibody production ✅
C. It reduces the weight of patients
D. Loss of memory power
880. DNA Ligase, used in recombinant DNA technology is obtained from:
A. E. coli only
B. E. coli and also Ligase encoded by T4 phage ✅
C. Saccharomyces
D. Retroviruses
881. Using genetic technique in forensic science is:
A. Genetic finger printing ✅
B. In vitro culture
C. Hybridoma technology
D. Gene therapy
882. A technique called southern blotting is used in:
A. Monoclonal antibody production
B. In vitro culture
C. Genetic finger printing ✅
D. Polymerase chain reaction
883. Genetic finger printing is useful in:
A. Identifying criminals involved in rape, murder etc. ✅
B. Establishing the parentage of a disputed child ✅
C. Identifying illegal immigrants ✅
D. All of these
884. RFLP is
A. Restriction fragment length polymorphism ✅
B. Repeated fragment length polymorphism
C. Renewed fragment length polymorphism
D. Required fragment length polymorphism
885. Gene therapy, a technique that helps in
A. Saving endangered species
B. Curing genetic disorders ✅
C. Clonal propagation
D. Producing monoclonal antibodies
886. A small, 15-30 bases long nucleotide sequences used to detect the presence of complementary sequences in DNA sample during DNA finger printing is called
A. RFLP
B. Probe ✅
C. VNTR
D. Reporter gene
887. A radioactive probe used in DNA finger printing contains
A. 32 P ✅
B. 14 C
C. 12 N
D. pUC18
888. Electrophoresis, a technique used in DNA fingerprinting helps to separate:
A. DNA segments ✅
B. Cells from DNA
C. Tissues
D. RNA from DNA
889. In DNA finger printing, even a smallest amount of DNA obtained from samples collected at crime place, can be multiplied into millions of copies by using a technique called:
A. Autoradiography
B. Southern blotting
C. Polymerase chain reaction ✅
D. Electrophoresis
890. Southern blotting is a technique used in genetic finger printing is called so because:
A. The blotting is done from the south side.
B. It was discovered by a scientist, E.M. Southern. ✅
C. It was popular in South-America.
D. It was popular in southern countries.
891. In DNA finger printing, the DNA from the gel is transferred to ______ for hybridization.
A. Nitrocellulose membrane ✅
B. Agarose
C. Autoradiogram
D. PCR
892. During DNA finger printing, DNA nucleotides hybridized with probe can be detected through:
A. Electrophoresis
B. Polymerase chain reaction
C. Autoradiography ✅
D. Hybridoma
893. In somatic cell gene therapy, the functional genes can be introduced into:
A. Sperm
B. Egg
C. Any body cells ✅
D. Germinal cells
894. During the recent tsunami disaster, a child was separated from its parents in Sri lanka. Later with the help of technique the child was made to reunite with its true parents. The technique is:
A. DNA finger printing ✅
B. Gene therapy
C. Tissue culture
D. Hybridoma technology
895. Genes have been transferred into animals with a view to obtain a large scale production of the proteins encoded by these genes in the milk, blood etc. This approach is also referred generally as
A. In vitro culture
B. Molecular farming ✅
C. Gene therapy
D. Hybridoma technology
896. RFLP, VNTR, Probe are some of the terminologies associated with:
A. Hybridoma technology
B. Tissue culture
C. DNA finger printing ✅
D. CFT
897. In 1990, the first gene-therapy was conducted on a 4-year-old girl in US. The girl was suffering:
A. AIDS
B. CANCER
C. SCID ✅
D. Malaria
898. SCID, a disease can be cured by Gene therapy is due to the deficiency of:
A. ADA enzyme ✅
B. Insulin
C. Glucagon
D. Dystrophin
899. A device in which a substrate of low value is utilized by living cells or enzymes to generate a product of higher value is called
A. Bioreactor ✅
B. Test tube culture
C. Electrophoresis
D. Chromatography
900. Gene therapy, a method to cure inherited disease by
A. Repairing the faulty gene
B. Introducing the correct copy of the gene ✅
C. Adding new cells to the body
D. Polymerase chain reaction
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