Blood Banking MCQs:

These 300+ multiple-choice questions (MCQs) are designed to test your knowledge and understanding of various aspects of blood banking, a critical component of transfusion medicine. Blood banking involves the collection, processing, testing, storage, and distribution of blood and blood components to ensure their safe and effective use in medical treatments. The questions cover a wide range of topics, including blood typing, compatibility testing, transfusion reactions, blood component therapy, and the management of adverse events. By answering these questions, you will gain a deeper insight into the complexities and importance of blood banking in modern healthcare.

MCQ Test
101. Which of the following red cell antigens are found on glycophorin-A?
A. M,N
B. Lea, Leb
C. S, s
D. P, P1, Pk
102. Paroxysmal cold hemoglobinuria (PCH) is associated with antibody specificity toward which of the following?
A. Kell system antigens
B. Duffy system antigens
C. P antigen
D. I antigen
103. Which of the following is a characteristic of anti-i?
A. associated with warm autoimmune hemolytic anemia
B. found in the serum of patients with infectious mononucleosis
C. detected at lower temperatures in the serum of normal individuals
D. found only in the serum of group O individuals
104. In case of cold autoimmune hemolytic anemia, the patient’s serum would most likely react 4+ at immediate spin with:
A. group A cells, B cells and O cells, but not his own cells
B. cord cells but not his own or other adult cells
C. all cells of a group O cell panel and his own cells
D. only penicillin-treated panel cells, not his own cells
105. Cold agglutinin syndrome is associated with an antibody-specificity toward which of the following?
A. Fy:3
B. P
C. I
D. Rh:1
106. Which of the following is a characteristic of anti-i?
A. often associated with hemolytic disease of the newborn
B. reacts best at room temperature or 4oC
C. reacts best at 37oC
D. is usually IgG
107. The Kell (K1) antigen is:
A. absent from the red cells of neonates
B. strongly immunogenic
C. destroyed by enzymes
D. has a frequency of 50% in the random population
108. In chronic granulomatous disease (CGD), granulocyte function is impaired. An association exists between this clinical condition and a depression of which of the following antigens?
A. Rh
B. P
C. Kell
D. Duffy
109. The antibodies of the Kidd blood group system:
A. react best by the indirect antiglobulin test
B. are predominantly IgM
C. often cause allergic transfusion reactions
D. do not generally react with antigen positive enzyme-treated RBCs
110. Proteolytic enzyme treatment of red cells usually destroys which antigen?
A. Jka
B. E
C. Fya
D. k
111. Anti-Fya is:
A. usually a cold-reactive agglutinin
B. more reactive when tested with enzyme-treated red blood cells
C. capable of causing hemolytic transfusion reactions
D. often an autoagglutinin
112. Resistance to malaria is best associated with which of the following blood groups?
A. Rh
B. I/i
C. P
D. Duffy
113. What percent of group O donors would be compatible with a serum sample that contained anti-X and anti-Y if X antigen is present on red cells of 5 to 20 donors, and Y antigen is present on red cells of 1 of 10 donors?
A. 2.5
B. 6.8
C. 25.0
D. 68.0
114. How many Caucasians is an population of 100,000 will have the following combination of phenotypes?
System Phenotype frequency(%)
ABO O 45
Gm Fb 48
PGM1 2-1 37
EsD 2-1 18
a. 1
A. 1
B. 14
C. 144
D. 1,438
115. What is the approximate probability of finding compatible blood among random Rh-positive units for a patient who has anti-c and anti-K? (Consider that 20% of Rh-positive donors lack c and 90% lack K)
A. 1%
B. 10%
C. 18%
D. 45%
116. A 25-year-old Caucasian woman, gravid 3, para 2, required 2 units of Red Blood Cells. The antibody screen was positive and the results of antibody panel are shown below:
Cell D C c E e K Jka Lea Leb M N P1 37oC AHG
1 + + 0 0 + + + 0 + + + 0 0
2 + + 0 0 + 0 + 0 + 0 0 0 0
3 + 0 + + 0 + 0 + + + + 0 1+
4 + + + 0 + 0 0 + + 0 + 0 1+
5 0 0 + 0 + 0 + 0 + 0 0 0 1+
6 0 0 + + + 0 + + 0 + 0 0 1+
7 0 0 + 0 + + + 0 + + + 0 1+
8 0 0 + 0 + 0 0 + 0 + + 0 1+
auto 0 0
What is the most probable genotype of this patient?
A. rr
B. r’r’
C. R0r
D. R1R1
117. A man suffering from gastrointestinal bleeding has received 20 units of Red Blood Cells in the last 24 hours and is still oozing post-operatively. The following results were obtained:
Test Result Control
PT 20 seconds 12 seconds
APTT 43 seconds 31 seconds
platelet count 160 x 103/uL 160-109/L
Hgb 10g/dL 100g/L
Factor VIII 85%
What blood product should be administered?
A. Fresh Frozen Plasma
B. Red Blood Cells
C. Factor VIII Concentrate
D. Platelets
118. Transfusion of which of the following is needed to help correct hypofibrinogenemia due to DIC?
A. whole blood
B. fresh frozen plasma
C. cryoprecipitated AHF
D. platelets
119. A blood component used in the treatment of hemophilia A is:
A. Factor VIII Concentrate
B. Fresh Frozen Plasma
C. Platelets
D. Whole Blood
120. Which of the following blood components is most appropriate to transfuse to an 8-year-old male hemophiliac who is about to undergo minor surgery?
A. Cryoprecipitated AHF
B. Red Blood Cells
C. Platelets
D. Factor VIII Concentrate
121. A unit of Fresh Frozen Plasma was inadvertently thawed and then immediately refrigerated at 4oC on Monday morning. On Tuesday evening this unit may still be transfused as a replacement for:
A. all coagulation factors
B. Factor V
C. Factor VIII
D. Factor IX
122. A newborn demonstrates petechiae, echymosis and mucosal bleeding. The preferred blood component for this infant would be:
A. Red Blood Cells
B. Fresh Frozen Plasma
C. Platelets
D. Cryoprecipitated AHF
123. Which of the following would be the best source of Platelets for transfusion in the case of alloimmune neonatal thrombocytopenia?
A. father
B. mother
C. pooled platelet-rich plasma
D. polycythemic donor
124. An obstetrical patient has had 3 previous pregnancies. Her first baby was healthy, the second has jaundiced at birth and required an exchange transfusion, while the third was stillborn. Which of the following is the most likely cause?
A. ABO incompatibility
B. immune deficiency disease
C. congenital spherocytic anemia
D. Rh incompatibility
125. A specimen of cord blood is submitted to the transfusion service for routine testing. The following results were obtained:
Test Result
anti-A 4+
anti-B negative
anti-D 3+
Rh-control negative
Direct antiglobulin test 2+
It is known that the father is group B, with the genotype of cde/cde. Of the following 4 antibodies, which 1 is the most likely cause of the positive direct antiglobulin test?
A. anti-A
B. anti-D
C. anti-c
D. anti-C
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