Leukemoid Reaction and Leukemia MCQs

1. Leukemoid reaction is due to all of the following except:
   • A. Pyogenic infection
   • B. Acute bleeding
   • C. Acute hemolysis
   • D. Gangrene
   • E. Chronic myeloid leukemia ✅


2. Leukemoid reaction is characterized by the following except:
   • A. Leucocytosis
   • B. Increased band forms
   • C. Shift to the right✅
   • D. Increased NAP score
   • E. Neutrophilia


3. Leukemoid reaction is characterized by:
   • A. Presence of Philadelphia chromosome
   • B. Low NAP score
   • C. High basophilia
   • D. Shift to the left✅
   • E. High eosinophilia


4. In Leukemoid reaction, all are true except:
   • A. Increased total leucocytic count up to 50,000/cmm
   • B. Occurs in severe infections
   • C. Characterized by the presence of immature WBCs in peripheral blood
   • D. Philadelphia chromosome positive ✅
   • E. NAP score is high


5. Leukemia is a malignant proliferation of hematopoietic cells in the:
   • A. Bone marrow then infiltrate peripheral blood and lymph nodes ✅
   • B. Lymph nodes then infiltrate peripheral blood and bone marrow
   • C. Peripheral blood then infiltrate bone marrow and lymph nodes
   • D. Bone marrow and doesn’t infiltrate lymph nodes
   • E. Lymph nodes and doesn’t infiltrate bone marrow or peripheral blood.


6. FAB classification classifies acute leukemia according to:
   • A. Cytogenetic abnormalities
   • B. Immunological characteristics
   • C. Both cytogenetic and immunological abnormalities
   • D. Morphological characteristics ✅
   • E. Morphological, phenotypic and cytogenetic characteristics


7. WHO classification for acute leukemia classifies it according to:
   • A. Morphological characteristics
   • B. Cytogenetic abnormalities
   • C. Both cytogenetic and immunophenotypic abnormalities✅
   • D. Morphological, immunophenotypic and cytogenetic characteristics
   • E. Morphological and immunophenotypic characteristics


8. The least number of bone marrow blast cell required to diagnose acute leukemia is:
   • A. Blast cells ≥ 30 %
   • B. Normoblasts ≥ 25 %
   • C. Blast cells ≥ 20 % ✅
   • D. Blast cells and normoblasts ≥ 30 %
   • E. Blast cells ≥ 60 %


9. Diagnosis and classification of acute leukemia needs:
   • A. Complete blood picture
   • B. Bone marrow examination
   • C. Immunophenotyping
   • D. Cytochemical stain
   • E. All of the above ✅


10. In acute myeloid leukemia, all of the following can be found except:
    • A. Myeloblasts
    • B. Megakaryoblasts
    • C. Lymphoblasts ✅
    • D. Erythroblasts


11. All of the following are a must to diagnose acute myeloid leukemia except:
    • A. More than 20 % blasts in Bone marrow
    • B. Blast cells in peripheral blood✅
    • C. Myeloperoxidase positivity
    • D. Presence of myeloid antigens on blast cells
    • E. None of the above


12. Presence of Auer rods in the blast cells indicated that they are:
    • A. Lymphoblasts
    • B. Myeloblasts ✅
    • C. Of no significance
    • D. Bilineage
    • E. Biphenotypic


13. Peroxidase stain positivity indicates:
    • A. Myeloblastic leukemia ✅
    • B. T-Lymphocytic leukemia
    • C. Common acute lymphoblastic leukemia
    • D. Megakaryoblastic leukemia
    • E. B-lymphoblastic leukemia


14. Acute lymphoblastic leukemia can present with all of the following except:
    • A. Anemia
    • B. Hypercellular bone marrow
    • C. Increased promyelocytes in peripheral blood ✅
    • D. Thrombocytopenia


15. In subacute leukemia, we can find the following except:
    • A. Leucopenia
    • B. Thrombocytopenia
    • C. Absence of blast cells in peripheral blood
    • D. 10 % blast cells in bone marrow✅


16. In acute lymphoblastic leukemia, all of the following can be found except:
    • A. Lymphoblast cells in peripheral blood
    • B. Hypercellular bone marrow
    • C. Blasts are myeloperoxidase positive ✅
    • D. Lymphadenopathy


17. All of the following is a must to diagnose acute lymphoblastic leukemia except:
    • A. More than 20 % blasts in bone marrow
    • B. Blast cells in peripheral blood✅
    • C. Myeloperoxidase negativity
    • D. Presence of lymphoid antigens on blast cells
    • E. None of the above


18. Diagnosis of acute leukemia requires the presence of at least:
    • A. 20 % blast cells in peripheral blood
    • B. 90 % blast cells in peripheral blood
    • C. 20 % blast cells in bone marrow ✅
    • D. 90 % blast cells in bone marrow


19. Lymphoproliferative disorders include all of the following except:
    • A. Hairy cell leukemia
    • B. Chronic lymphocytic leukemia
    • C. Non Hodgkin’s lymphoma
    • D. Chronic myeloid leukemia ✅


20. Neutrophil alkaline phosphatase in acute leukemia:
    • A. Constantly low
    • B. Constantly high
    • C. Variable ✅
    • D. Used mainly to diagnose lymphoblastic leukemia
    • E. None of the above