Autoimmune Diseases MCQs
- As regard ANA testing in SLE cases which of the following is true?
- Done by indirect immunofluorescence
- It is a sensitive screening test for the disease
- Its specificity can be improved by detection of high titers
- All of the above ✅
- In cases of rheumatoid arthritis which of the following statements is false:
- Negative RF by routine lab procedures excludes diagnosis ✅
- RF by Rose Waaler is more specific than latex fixation test
- RFs are antiglobulins against autologous IgG
- None of the above
- Hasimoto’s disease and Graves’s disease are similar in that both:
- Affect RBCs
- Affect the liver
- Are forms of cellular immunity
- Affect the thyroid gland ✅
- Are accompanied by histamine release
- Children with insulin dependent DM have:
- Anti-IgG Fc antibodies
- Anti-microsomal antibodies
- Anti-parietal cells antibodies
- Antinuclear antibodies
- None of the above ✅
- An autoimmune disease characterized by the overproduction of thyroid hormones:
- Lupus erythematosus
- Myasthenia graves
- DiGeorge disease
- Grave’s disease ✅
- Hemolytic anemia
- Rheumatoid arthritis is an autoimmune disorder in which the body’s immune system acts against its own:
- Lymphocytes
- Neutrophils
- RBC
- IgG ✅
- DNA
- Sero-negative rheumatoid arthritis (RA) includes the following:
- Early RA
- Juvenile RA
- Arthritis with certain systemic diseases
- All of the above ✅
- None of the above
- The pathogenic antibody in Grave’s disease has specific for:
- Nuclei
- Thyroid peroxidase
- Thyroglobulin
- TSH receptors ✅
- TSH
- Direct immunofluorescent examination of renal biopsy shows linear deposition along the glomerular basement membrane:
- Minimal change nephropathy
- Membranous nephropathy
- Membranoproliferative glomerulonephritis
- Anti-GBM nephritis ✅
- IgA nephropathy
- Which of the following is a non-organ specific autoimmune disease?
- Myasthenia graves
- Insulin dependent diabetes
- Rheumatoid arthritis ✅
- Hasimoto’s thyroiditis
- Pernicious anemia
- Which of the following statements about anti-mitochondrial antibodies is false:
- Found in patients with primary biliary cirrhosis (PBC)
- Found in some patients of chronic active hepatitis
- Can’t differentiate PBC from primary sclerosing cholangitis ✅
- Accompanied by a rise in serum IgM in patients with PBC
- None of the above
- Patients with SLE show the following findings:
- Normocytic normochromic anemia
- High ESR
- Thrombocytopenia
- Leucopenia
- All of the above ✅
- Specificity of ANA testing by immunofluorescence can be increased by:
- Determination of titre
- Determination of pattern
- Using more than one substrate
- All of the above ✅
- None of the above
