Autoimmune Diseases MCQs
- Anti-n-DNA antibodies in SLE are:
- Associated with kidney affection
- Used in diagnosis and follow-up
- Detected by IIF technique
- All of the above ✅
- None of the above
- In rheumatoid arthritis, detection of RF by latex agglutination test is:
- Sensitive but not specific ✅
- Results in high incidence of false negative
- Both sensitive and specific
- None of the above
- All of the following is true for IC glomerulonephritis except:
- Diminished serum complement levels
- Detection of circulating immune complexes
- Patient’s serum may be positive for ANA or anti-DNA
- Linear deposits of immunoglobulins and complement in the glomeruli ✅
- All of the above
- In individuals with IC glomerulonephritis which of the following tests should be done:
- ANA
- Anti-DNA
- Serum complement level
- Detection of CIC
- All of the above ✅
- Anti-GBM antibodies can cause:
- Glomerulonephritis
- Goodpastur’s syndrome
- Idiopathic pulmonary hemosiderosis
- All of the above ✅
- None of the above
- Anti-n DNA antibodies are all of the following except:
- Diagnostic for SLE
- Correlate with SLE activity
- Indicate kidney affection
- Cannot be used for follow-up ✅
- None of the above
- In SLE all of the following indicate activity except:
- Elevated ESR
- High C3 and C4 ✅
- High anti n –DNA titre
- High levels of circulating immune complexes
- None of the above
- In SLE all of the following autoantibodies support the diagnosis except:
- ANA
- Anti-n DNA
- Anti-Smith
- Anti-smooth muscle ✅
- Anti RNP
- For diagnosis and follow-up of SLE which is false:
- Serum ANA is used for screening
- Anti-nDNA & Anti-Sm are diagnostic
- For activity, ESR, C3, C4 & CIC are done
- For follow-up ANA titre is done ✅
- CBC, urine analysis & kidney function are done in follow-up
- In systemic lupus erythematosus, all are true except:
- Serum complement is frequently reduced
- CICs levels donot correlate with disease activity ✅
- High titre ANAs by IIF is a sensitive screening test
- High titre anti-ds-DNA is associated with renal affection
- Anti-Sm antibodies are specific
- The following is true about rheumatoid arthritis:
- RFs are antiglobulins directed against the Fc fragment of autologous IgG
- Rose Waaler test for detection of RF is specific yet not sensitive
- Serum complement levels are usually normal
- A negative RF does not exclude diagnosis of rheumatoid arthritis
- All of the above ✅
- All are true concerning immune hemolytic anamias except:
- It may be drug induced such as by penicillin and methyl dopa
- Diagnosis is by anti-globulin test (Coombs test)
- Rh incompatibility is not an example of alloantibody – induced hemolytic anemia ✅
- Warm anti-body type is either idiopathic or secondary to SLE, leukemia, etc….
- None of the above
- All of the following are diagnostic importance in autoimmune disease except:
- Lesions are detected by biopsy
- Immune complexes are found in serum
- Decreased levels of serum complement
- Decreased serum gamma globulin levels ✅
- All of the above
