Autoimmune Diseases MCQs
- Any of the following are consistent with diagnosis of autoimmune hepatitis except:
- Positive ANA
- Positive ASMA
- Positive AMA
- Positive HBsAg✅
- None of the above
- ANA and rheumatoid factor may be associated with all of the following conditions except:
- Rheumatoid arthritis
- Sjogren’s syndrome
- SLE
- ITP ✅
- None of the above
- Which of the antibodies are most useful for the diagnosis of pernicious anemia:
- Anti-parietal cell ✅
- Anti-thyroid peroxidase
- Anti-nuclear
- Anti-IgG Fc
- Anti – TSH receptor
- Which of the following antibodies are most useful for diagnosis of Sjogren syndrome:
- Anti-cardiolipin antibodies
- Anti-neutrophil cytoplasmic antibodies (ANCA)
- Anti-ssA(RO), anti-ssB(La) antibodies ✅
- Anti-mitochondrial antibodies
- Anti-glomerular basement membrane antibodies
- Children with insulin dependent DM usually have serum antibodies to:
- Mitochondria
- Thyroid microsomes
- Gastric parietal cells
- Nuclear antigens
- None of the above✅
- In SLE which of the following is false:
- Circulating immune complexes level correlates with disease activity
- Serum complement is frequently decreased
- Positive ANA is found in 95% of active untreated cases
- Anti-DNA is associated with kidney affection
- ANA titre correlate with disease activity ✅
- In autoimmune chronic hepatitis which of the following is true:
- Organ specific autoimmune disease✅
- Positive anti-Ro anti-La antibodies
- Positive HBsAg
- Positive anti-Sm antibodies
- Positive ANCA
- In Hashimoto’s thyroiditis which of the following is true:
- Inflammatory disorder of unknown etiology
- Euothyrodism is early in the disease
- Late in the disease hypothyroidism often occurs
- Autoantibodies to thyroglobulin and thyroid microsomal antigens are found
- All of the above ✅
- In autoimmune chronic hepatitis which of the following is true:
- Non organ specific autoimmune disease
- Positive anti –Ro and anti – La antibodies
- Positive HBsAg
- Positive Anti-Sm antibodies
- Positive anti smooth antibodies✅
- In primary biliary cirrhosis which of the following is false:
- Anti mitochondrial antibodies are positive
- AMA can’t differentiate it from primary sclerosing cholangitis ✅
- Bilirubin is elevated
- IgM is increased
- Alkaline phosphatase is usually elevated
- All of the following are consistent with diagnosis of autoimmune hepatitis except:
- HCV Ab positive ✅
- Positive liver specific antibodies
- Positive anti-LKM antibodies
- Polyclonal hypergammaglobulinemia
- Positive ANA
- In rheumatoid arthritis which of the following is false:
- RFs are antiglobulins directed against the Fc fragment of autologous IgG
- Rose Waaler test for detection of RF is specific yet not sensitive
- Serum complement levels are usually normal
- A negative RF by lab procedure does exclude diagnosis of rheumatoid arthritis ✅
- None of the above
- A positive ANA test can be found in all of the following except:
- SLE
- Sjogren’s syndrome
- Rheumatoid arthritis
- Scleroderma
- Multiple sclerosis ✅
