Red Blood Cells (RBCs) MCQs
- In G6PD deficiency diagnosis is established by estimation of the enzyme:
- In between attacks (6 weeks after the attack)✅
- During the attack
- Immediately after the attack
- At any time irrespective of the attack
- After ingestion of fava beans
- In pyruvate kinase enzyme deficiency all of the following are true except:
- It is inherited as an autosomal recessive trait
- RBC morphology is normal
- Diagnosis is established by enzyme assay
- Resulting anemia is normochromic normocytic
- Resulting anemia is macrocytic ✅
- Causes of warm autoimmune hemolytic anemia include all of the following except:
- Idiopathic
- Chronic lymphatic leukemia
- Viral infections
- Collagen disorders as SLE
- Hereditary ✅
- Laboratory diagnosis of warm autoimmune hemolytic anemia includes all of the following except:
- Mild normochromic normocytic anemia
- Blood film shows nucleated RBCs, polychromasia, and spherocytes
- Laboratory evidence of hemolysis
- Positive direct Coomb’s test
- Positive indirect Coomb’s test ✅
- Causes of cold autoimmune hemolytic anemia include all of the following except:
- Idiopathic
- Mycoplasma pneumonia
- Viral infections as infectious mononucleosis
- Lymphoproliferative disorders as non-Hodgkin’s lymphoma
- Bacterial infections ✅
- Laboratory diagnosis of cold autoimmune hemolytic anemia include:
- Evidence of chronic hemolysis with exacerbations especially when the patient is chilled
- Normochromic normocytic anemia with polychromasia
- Cold antibodies in serum
- Positive indirect Coomb’s test
- All of the above ✅
- Haemolytic disease of the newborn may be due to all of the following except:
- Rh incompatibility (mostly anti-D)
- ABO incompatibility
- Minor group incompatibility
- Rh incompatibility (mostly anti-C) ✅
- None of the above
- In Rh hemolytic disease of the newborn, laboratory features of cord blood include all of the following except:
- Anemia, reticulocytosis, normoblastemia
- Jaundice
- Increased indirect serum bilirubin
- Direct Coomb’s test is positive
- Indirect Coomb’s test is positive ✅
- In ABO incompatibility disease of the newborn, all of the following are true except:
- The disease is milder because A and B antigens are weak in the fetus
- It can occur in the first pregnancy without prior sensitization
- Anemia and mild jaundice
- Blood film shows spherocytes and reticulocytes
- Coombs’ test is strongly positive ✅
- Normal hemoglobin pattern in adult life is all of the following except:
- HbA: 96 – 98 %
- HbA2: 2-3.4 %
- HbF: < 1 %
- HbS: < 1 % ✅
- Sickle cell disease is characterized by all of the following except:
- Results from a genetic abnormality in Hb structure
- Marked normocytic normochromic anemia
- Hb electrophoresis shows SS pattern
- Hb electrophoresis shows AS pattern ✅
- Sickle cells in the stained film
- Normal hemoglobin electrophoresis pattern found in:
- Sickle cell disease
- Beta thalassemia intermedia
- Beta thalassemia trait
- Beta thalassemia major
- Alpha thalassemia trait ✅
- Immune hemolytic anemia can occur in all of the following except:
- Lymphoproliferative disorders
- Viral infections
- Collagen disorders
- Iron deficiency anemia ✅
- Alloimmune hemolytic anemia can occur in all of the following except:
- Lymphoproliferative disorders ✅
- Rh incompatibility
- ABO incompatibility
- Minor group incompatibility
