- Which of the following are true about cholesterol?
- A. The sterol ring of the cholesterol molecule can be broken down further
- B. The peripherally synthesized or intestinally absorbed cholesterol is transported to the liver where it is partly converted to bile acids and the remainder excreted unchanged into the intestine via the bile, which serves as an emulsifying agent
- C. 25 to 40% of the cholesterol in the plasma is present as esterified and the remaining 60-75% as free “unesterified.”
- D. Most of the cholesterol is transported in the plasma via low density lipoprotein
- A. only 1 and 3 are correct
- B. only 2 and 4 are correct ✅
- C. only 1,2, and 3 are correct
- D. 1,2,3 and 4 are correct
- It is generally agreed that coronary heart disease is infrequent at cholesterol level <160mg/dL and the value that constitutes a threshold value beyond which the risk of disease rises at first:
- A. 200 mg/dL
- B. 250mg/dL
- C. 300mg/dL
- D. 350mg/dL ✅
- In cholesterol assay:
- A. serum values are about 3% higher than plasma values
- B. a three-minute venous compression can increase cholesterol values by up to 10%
- C. ascorbic acid and methyldopa or metamizol lead to lower cholesterol values
- D. plasma and serum may be stored for cholesterol assay for up to 4 days at 4C.
- A. only 1 and 3 are correct
- B. only 2 and 4 are correct
- C. only 1,2, and 3 are correct
- D. 1,2,3 and 4 are correct ✅
- Which of the following interfering factors result in too low triglyceride values because the substances can react with H2O2?
- A. hemoglobin
- B. ascorbic acid
- C. heparin
- D. bilirubin
- A. only 1 and 3 are correct
- B. only 2 and 4 are correct ✅
- C. only 1,2, and 3 are correct
- D. 1,2,3 and 4 are correct
- Precipitation of VLDL and LDL can be achieved with:
- A. phosphotungstic acid/ MgCl2
- B. heparin/MnCl2
- C. Polyethylene glycol 6000
- D. dextran sulfate/ MgCl2 ✅
- Which of the following equations is the correct Friedewald’s formula?
- A. LDL cholesterol = Cholesterol – Triglyceride / 5 – HDL cholesterol(mg/dL)
- B. LDL cholesterol = Cholesterol – Triglyceride /10 – HDL cholesterol(mg/dL)
- C. LDL cholesterol = Triglyceride – Cholesterol /2.2 – HDL cholesterol(mg/dL)
- D. LDL cholesterol = Triglyceride – Cholesterol / 5 – HDL cholesterol(mg/dL) ✅
- This apolipoprotein makes up more than 95% of the protein coat of LDL:
- A. apo A-I
- B. apo A-II
- C. apo B100 ✅
- D. apo C
- These are the principal apolipoproteins of HDL:
- A. apo A-I
- B. apo B100
- C. apo A-II
- D. apo-B48
- This apolipoprotein is the activator of LCAT:
- A. apo A-I ✅
- B. apo A-II
- C. apo A-III
- D. apo A-IV
- Which apolipoprotein is associated with Tangier disease?
- A. apo A-I ✅
- B. apo A-II
- C. apo A-III
- D. apo A-IV
- Which apolipoprotein is the cofactor of lipoprotein lipase?
- A. apo C-I
- B. apo C-II ✅
- C. apo C-III
- D. apo C-IV
- Lp(a) is increased in:
- A. nephritic syndrome
- B. uremic patient undergoing hemodialysis
- C. patients with uncontrolled DM
- D. patients with hyperthyroidism
- A. only 1 and 3 are correct
- B. only 2 and 4 are correct
- C. only 1,2, and 3 are correct ✅
- D. 1,2,3 and 4 are correct
- Which of the following statements are correct about LDL:
- A. LDL are formed by the hydrolysis of VLDL
- B. LDL are mainly responsible for carrying cholesterol to peripheral cells
- C. LDL are the only lipoprotein class possessing a single apolipoprotein, apo B100.
- D. LDL on electrophoretic separation migrate in the a-globulin position
- A. only 1 and 3 are correct
- B. only 2 and 4 are correct
- C. only 1,2, and 3 are correct ✅
- D. 1,2,3 and 4 are correct
- Which of the following statements are correct about HDL:
- A. HDL are the smallest lipoproteins
- B. HDL has the highest protein content
- C. HDL float in the ultracentrifuge at a density of 1.063 to 1.21
- D. HDL facilitate and accelerate the clearance of cholesterol from cells and vascular walls and its transport to the liver.
- A. only 1 and 3 are correct
- B. only 2 and 4 are correct
- C. only 1,2, and 3 are correct
- D. 1,2,3 and 4 are correct ✅
- According to Fredrickson classification of primary hyperlipoproteinemias, which of the following do not match?
- A. type I : fat-induced hypertriglyceridemia
- B. type II : hypercholesterolemia
- C. type III : combined endogenous and exogenous triglyceridemia ✅
- D. type IV : endogenous triglyceridemia
Pages: 1 2
