Hepatitis B, Hepatitis C, and Related Topics MCQs

Hepatitis B, Hepatitis C, and Related Topics MCQs

  1. Detection of low titer HBcAb IgG and positive HBsAb denotes:
    • A. HBV past infection with immunity to HBV ✅
    • B. HBV carrier status
    • C. HBV vaccination
    • D. HBV acute infection
    • E. HBV chronic infection

  2. Co-infection of HDV and HBV is diagnosed by:
    • A. Positive HBsAg and HBcAb IgG
    • B. Positive HDV Ab IgM and HBcAb IgM✅
    • C. Positive HBsAb and positive HDV Ab IgM
    • D. Negative HBs Ab and positive HDV Ab IgM
    • E. None of the above

  3. Super infection of HDV on HBV infection is diagnosed by:
    • A. Positive HDV Ab IgG and HBcAb IgG
    • B. Positive HBs Ab and HDV Ab IgM
    • C. Negative HBs Ag and positive HDV Ab IgM
    • D. Positive HDV Ab IgM and HDV Ab IgG
    • E. Positive HBc Ab IgG, HBs Ag and HDV Ab IgM ✅

  4. Super infection of HDV and HBV is diagnosed by:
    • A. Positive HDV Ab IgM and HBc Ab IgG and negative HBsAg
    • B. Positive HBs Ab and positive HDV Ab IgG
    • C. Negative HBs Ag and positive HDV Ab IgM
    • D. Positive HDV Ab IgG and HBcAb IgG
    • E. None of the above ✅

  5. As regards hepatitis B, which of the following is true:
    • A. Persistence of HBsAg >6 months is an indicator of chronicity ✅
    • B. Serum HBcAg indicates viral replication
    • C. It is transmitted through feco-oral route
    • D. Positive HBcAb and +ve HBsAb denotes post vaccination
    • E. HBsAb indicated viral replication

  6. As regards hepatitis B, which of the following is not true:
    • A. Persistence of HBsAg > 6 months is an indicator of chronicity
    • B. Positive HBeAg indicates viral replication
    • C. Positive HBsAB indicates immunity
    • D. Positive HBvAb and +ve HBsAb denotes post vaccination ✅
    • E. HBcAb is the only marker in the window gap

  7. As regards HBc Ab, which of the following is false:
    • A. It is an important serologic marker in the window gap
    • B. High titer IgG despite positive HBsAb indicates persistent viral load ✅
    • C. Low titer IgG with positive HBsAb indicates past infection and immunity
    • D. Negative HBcAb IgG with positive HBsAb denotes post vaccination

  8. The most definitive diagnostic test for HCV infection is:
    • A. HCV Ab IgG by ELIZA
    • B. HCV Ab IgM by ELIZA
    • C. Recombinant immunoblot assay (RIBA)
    • D. Viral RNA by PCR ✅

  9. Which of the following tests is clinically significant for HCV infection:
    • A. HCV Ab by ELIZA
    • B. HCV Ab by RIBA
    • C. HCV RNA BY PCR
    • D. Serotyping and quantitation of viral load
    • E. All of the above ✅

  10. Carrier state in viral infection means:
    • A. The virus is hidden in the host cell and can’t be detected
    • B. The virus is secreted by the host after clinical recovery ✅
    • C. The virus does not remain in the host after recovery
    • D. None-of the above
    • E. All of the above

  11. PCR is used to detect:
    • A. Viral antigen
    • B. Viral particles
    • C. Viral genome ✅
    • D. Viral envelope
    • E. None of the above

  12. Primary biliary cirrhosis could be differentiated from primary sclerosing cholangitis by:
    • A. Increased ALP and GGT
    • B. Evidence of hepatic dysfunction
    • C. Increased total IgM
    • D. Frequently progresses to chronic hepatitis
    • E. Positive AMA ✅

  13. The following is true for hepatocellular carcinoma:
    • A. Mild elevation of AFP occurs in primary hepatoma
    • B. Mild elevation of AFP plus elevation of CEA occurs in secondary liver cancer✅
    • C. Normal level of CEA with increased levels of AFP occur in colorectal cancer without hepatic malignancy
    • D. All of the above

  14. Tumor markers for liver metastasis include:
    • A. CEA ✅
    • B. ALP
    • C. Transaminases
    • D. All of the above
    • E. None of the above

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